Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women

Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men

NAD synthesis in animal tissues

Deficiency of Reduced Nicotinamide-Adenine Dinucleotide Oxidase in Chronic Granulomatous Disease

Studies on the rate of reduction of hepatic microsomal cytochrome P-450 by reduced nicotinamide adenine dinucleotide phosphate: effect of drug substrates

Levels of nicotinamide adenine dinucleotide and reduced nicotinamide adenine dinucleotide in facultative bacteria and the effect of oxygen

Physiological roles of ketone bodies as substrates and signals in mammalian tissues

Digestion and absorption of NAD by the small intestine of the rat

Degradation of NAD by synaptosomes and its inhibition by nicotinamide mononucleotide: implications for the role of NAD as a synaptic modulator

Oxidant injury of cells. DNA strand-breaks activate polyadenosine diphosphate-ribose polymerase and lead to depletion of nicotinamide adenine dinucleotide

Metabolism of nicotinamide mononucleotide in beef liver

Carbohydrate restriction regulates the adaptive response to fasting

Distorted distribution of nicotinamide-adenine dinucleotide phosphate-diaphorase neurons in temporal lobe of schizophrenics implies anomalous cortical development

Oxygen radicals as second messengers for expression of the monocyte chemoattractant protein, JE/MCP-1, and the monocyte colony-stimulating factor, CSF-1, in response to tumor necrosis factor-alpha and immunoglobulin G. Evidence for involvement of reduced nicotinamide adenine dinucleotide phosphate (NADPH)-dependent oxidase

Determining NAD synthesis in erythrocytes

Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity

Effects of high-intensity resistance training on untrained older men. II. Muscle fiber characteristics and nucleo-cytoplasmic relationships

Characterization of recombinant human nicotinamide mononucleotide adenylyl transferase (NMNAT), a nuclear enzyme essential for NAD synthesis

Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease

A randomized trial of a low-carbohydrate diet for obesity

Reconstructing eukaryotic NAD metabolism

The new life of a centenarian: signalling functions of NAD(P)

Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans

Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms

Stimulation of nicotinamide adenine dinucleotide biosynthetic pathways delays axonal degeneration after axotomy

A high-fat, ketogenic diet induces a unique metabolic state in mice

Vitamins and aging: pathways to NAD+ synthesis

Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme

Neuroendocrine factors in the regulation of inflammation: excessive adiposity and calorie restriction

Normal fasting plasma glucose and risk of type 2 diabetes diagnosis

The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies

Perivascular adipose tissue-derived visfatin is a vascular smooth muscle cell growth factor: role of nicotinamide mononucleotide

Nampt: linking NAD biology, metabolism and cancer

The role of NAD biosynthesis in plant development and stress responses

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

Nicotinamide/nicotinic acid mononucleotide adenylyltransferase, new insights into an ancient enzyme

Extracellular PBEF/NAMPT/visfatin activates pro-inflammatory signalling in human vascular smooth muscle cells through nicotinamide phosphoribosyltransferase activity

Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle

Extending healthy life span--from yeast to humans

How to Know if You're Pre-Diabetic - Life Extension

PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation

NAD blocks high glucose induced mesangial hypertrophy via activation of the sirtuins-AMPK-mTOR pathway

The effect of the Spanish Ketogenic Mediterranean Diet on nonalcoholic fatty liver disease: a pilot study

A 45-minute vigorous exercise bout increases metabolic rate for 14 hours

Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice

The ketogenic diet as a treatment paradigm for diverse neurological disorders

The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity

The dynamic regulation of NAD metabolism in mitochondria

Leucine supplementation increases SIRT1 expression and prevents mitochondrial dysfunction and metabolic disorders in high-fat diet-induced obese mice

NAD+ biosynthesis ameliorates a zebrafish model of muscular dystrophy

Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models

Ketone body metabolism and cardiovascular disease

Anti-diabetic and anti-lipidemic effects of chlorogenic acid are mediated by ampk activation

The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

Mitochondrial complex I deficiency increases protein acetylation and accelerates heart failure

The importance of NAMPT/NAD/SIRT1 in the systemic regulation of metabolism and ageing

Circadian clock NAD+ cycle drives mitochondrial oxidative metabolism in mice

Ketone bodies as signaling metabolites

Nicotinamide riboside, a trace nutrient in foods, is a vitamin B3 with effects on energy metabolism and neuroprotection

Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging

Partial reversal of skeletal muscle aging by restoration of normal NAD? levels

NAD+ and sirtuins in aging and disease

NAD(+)-dependent activation of Sirt1 corrects the phenotype in a mouse model of mitochondrial disease

Specific ablation of Nampt in adult neural stem cells recapitulates their functional defects during aging

SIRT2 induces the checkpoint kinase BubR1 to increase lifespan

Effect of exercise intensity on post-exercise oxygen consumption and heart rate recovery

Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3

Nicotinamide mononucleotide, an intermediate of NAD+ synthesis, protects the heart from ischemia and reperfusion

Nicotinamide mononucleotide improves energy activity and survival rate in an in vitro model of Parkinson's disease

Regulation of NAD+ metabolism, signaling and compartmentalization in the yeast Saccharomyces cerevisiae

Novel assay for simultaneous measurement of pyridine mononucleotides synthesizing activities allows dissection of the NAD(+) biosynthetic machinery in mammalian cells

Inhibition of de novo NAD(+) synthesis by oncogenic URI causes liver tumorigenesis through DNA damage

Boosting NAD to spare hearing

Activation of SIRT3 by the NAD? precursor nicotinamide riboside protects from noise-induced hearing loss

The effect of different exercise regimens on mitochondrial biogenesis and performance

Calorie restriction-mediated replicative lifespan extension in yeast is non-cell autonomous

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease

Effect of nicotinamide mononucleotide on brain mitochondrial respiratory deficits in an Alzheimer's disease-relevant murine model

NK cells link obesity-induced adipose stress to inflammation and insulin resistance

Pharmacological NAD-Boosting Strategies Improve Mitochondrial Homeostasis in Human Complex I-Mutant Fibroblasts

Reduced Ssy1-Ptr3-Ssy5 (SPS) signaling extends replicative life span by enhancing NAD+ homeostasis in Saccharomyces cerevisiae

Chlorogenic acid improves late diabetes through adiponectin receptor signaling pathways in db/db mice

Interventions to Slow Aging in Humans: Are We Ready?

SARM1 activation triggers axon degeneration locally via NAD? destruction

Nicotinamide Riboside Ameliorates Hepatic Metaflammation by Modulating NLRP3 Inflammasome in a Rodent Model of Type 2 Diabetes

A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan

NAD(+) Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

Regulation of AMP-activated protein kinase by natural and synthetic activators

Less is more: Nutrient limitation induces cross-talk of nutrient sensing pathways with NAD + homeostasis and contributes to longevity

Ketosis may promote brain macroautophagy by activating Sirt1 and hypoxia-inducible factor-1

The "Big Bang" in obese fat: Events initiating obesity-induced adipose tissue inflammation

Generation, Release, and Uptake of the NAD Precursor Nicotinic Acid Riboside by Human Cells

Lethal Cardiomyopathy in Mice Lacking Transferrin Receptor in the Heart

Fasting and refeeding differentially regulate NLRP3 inflammasome activation in human subjects

Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice

Antitumor effect of combined NAMPT and CD73 inhibition in an ovarian cancer model

Dietary restriction with and without caloric restriction for healthy aging

AMPK activation protects cells from oxidative stress-induced senescence via autophagic flux restoration and intracellular NAD(+) elevation

Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice

Enhancing NAD+ Salvage Pathway Reverts the Toxicity of Primary Astrocytes Expressing Amyotrophic Lateral Sclerosis-linked Mutant Superoxide Dismutase 1 (SOD1)